Due to the demographic evolution in the world, the need for therapies that help to optimize aging have emerged. Their main objective is to improve the quality of people’s lives. This type of medicine is known as Antiage Therapy.

Recent scientific advances are helping us understand the aging process, and have given birth to antiaging medicine. This is based on measures that slow down, stop and even reverse the effects of aging, as well as increase life expectancy.

There are different medical-nutritional interventions, and in this article I will explore the main ones.

Of all the measures studied, caloric restriction, i.e., reducing the amount of energy we consume (without creating a nutritional deficit), is the one that shows the greatest potential. (1,2). Among the benefits attributed to this nutritional intervention are protection against obesity, cardiovascular disease, hypertension, and cancer (3).

Aging reduces the ability to produce hormones, and low hormone levels are associated with skin changes, decreased muscle mass, bone density, and mood swings. Aging also influences intellectual activity, sexual desire, and sexual potential (4,5,6).

Testosterone replacement therapy increases muscle and bone mass, as well as strength (7). It also supports various cognitive functions like language, spatial ability, and memory (8). In menopausal women, DHEA therapy appears to be very beneficial. These therapies can have adverse effects like polycythemia (increased hemoglobin and red blood cells), venous thrombosis, and prostate cancer.
This kind of intervention’s contraindications include: suspected prostate cancer, having severe urinary symptoms, elevated hemoglobin, coronary artery disease, uncontrolled heart failure, and untreated sleep apnea (8).

The intestinal microbiota (set of micro-organisms present in the intestine) needs to be considered. Its role in regulating health and life expectancy has been proven (9). Specifically, the intestinal microbiota is important when it comes to resisting infections, inflammation, autoimmunity, and cancer. It regulates the brain-intestine axis (10). Therefore, combining nutritional intervention with supplements that improve the intestinal microbiota is advantageous in Antiage Therapy.

Vitamin D plays an important role in metabolizing calcium. Its deficiency has been linked to cognitive decline and Alzheimer’s, loss of muscle mass, osteoporosis, as well as heart problems like heart failure and coronary artery disease (11, 12, 13, 14). A recent study on vitamin D reported anticancer effects, and that it inhibited the growth of different types of cancer (15). In this context, several scientific organizations have developed recommendations to perform vitamin D therapy. I know that vitamin D will be the main source of antiaging medicine in the near future, due to its numerous beneficial effects on the elderly population.

In this care, the patient’s condition, expectations, and objectives are assessed to decide what type (s) of Antiage Therapy can be applied in each particular case.